
(4R,4aR,5R,6S,7S,8S,8aR,10S,12S)-2-azaniumylidene-4,6,8,12-tetrahydroxy-6-(hydroxymethyl)-2,3,4,4a,5,6,7,8-octahydro-1H-8a,10-methano-5,7-(epoxymethanooxy)quinazolin-10-olate (Tetrodotoxin, TTX)
A common staple of modern horror and science fiction/fantasy media are the undead human corpses known as zombies, which find their origins in Haitian folklore as the “zombi” or “zonbi” that serve as mindless drudges to the will of a sorcerer. The sorcerer or “bokor” in the traditional Vodou religion is a necromancer, who supposedly can place a living person under a spell, turning them into a zombi using a combination of deliriant drugs such as datura, and a powerful nerve agent called tetrodotoxin, in powdered form.
TTX is a highly dangerous neurotoxin that acts to block the passage of sodium ions into the neurons, preventing them from carrying nerve signals and effectively stopping the muscles from being able to move in response to nerve inputs. This paralysis extends to all voluntary muscles including the diaphragm and the muscles between the ribs, thus shutting down breathing often with fatal results.
There is no specific antidote for human use, but if the dosage is sufficiently mild and the patient survives for 24 hours after exposure, recovery is possible with little or no lasting damage.If this looks confusing, that’s because it is. However, the modeling is accurate.
